Acquired Immuno deficiency syndrome (AIDS) is a serious pandemic public health problem caused by Human Immunodeficiency virus (HIV). It usually breaks down the acquired immune system and leading to develop life threatening opportunistic infections, neurological disorders and unusual malignancies. AIDs can be categorized into four broad headings such as initial infection with virus and development of antibodies, asymptomatic carrier stage, AIDS related complexes (ARCs) and AIDS. From initial infection to development of sign and symptoms are called window period. During the window period, progressive loss of acquired immunity leads to develop a highly susceptible host environment for different pathogenic agents. For the consequences, different opportunistic organisms are harboring in the host and presenting AIDS related complexes like fever, weight loss, prolonged diarrhoea, minor opportunistic infections, and lymphadenopathy. It has been claimed that people who are died in the AIDS are not due to HIV but due to ARCs. Until, no significantly effective medicine has been invented in the world to minimize the consequences of ARCs. Few studies suggested that some herbal medicines have shown significant effect to reduce the morbidity and mortality of ARCs. It is an initial step to assimilate the scientific evidences in the article for drug development to minimize the drastic effects of ARCs.