{"references": ["1. Drance SM: The changing concept of glaucoma in the 20th century. In: van Buskirk EM, Shields MB, editors: 100 years of progress in glaucoma, Philadelphia, Lippincott-Raven, 1997. 2. Fronimopoulos J, Lascaratos J. The terms glaucoma and cataract in the ancient Greek and Byzantine writers. Doc Ophthal. 1991;77(4):369-375. 3. Thylefors B, N\u00e9grel AD, Pararajasegaram R, Dadzie KY. Global data on blindness [review]. Bull World Health Org. 1995;73(1):115-121. 4. Quigley HA: Number of people with glaucoma worldwide. Br J Ophthalmol. 1996;80:389. 5. Thylefors B, Negrel AD: The global impact of glaucoma. Bull World Health Organ. 1994;72:323. 6. Quigley H, Broman A: Number of people with glaucoma worldwide in 2010 and 2020. Br J Ophthalmol. 2006; 90:262. 7. Johnson G, Quigley H: The glaucomas. In: Johnson G, Minassian D, Weale R, West S, editors: The nd epidemiology of eye disease, 2 Edn., London, Arnold, 2003.pp;222\u2013239. 8. Jayachanderdas, Ziachaudhary, Profile of glaucoma in major eye hospital in north India;2001:49,25-30. 9. Tham YC, Li X, Wong TY, Quigley HA, Aung T1, Cheng CY. Global prevalence of glaucoma and projections of glaucoma burden through 2040: a systematic review and meta-analysis. Ophthalmology. 2014 Nov;121(11):2081-90. doi: 10.1016/j.ophtha. 2014.05.013. 10. G o r d o n M O , B e i s e r J A , B r a n d t J D , H e u e r DK,Higginbotham EJ, et al.: for the Ocular Hypertension Treatment Study Group The Ocular Hypertension Treatment Study: baseline factors that predict the onset of primary open-angle glaucoma. Arch Ophthalmol. 2002;120(6):714-720. doi:10.1001/ archopht.120.6.714. 11. Leske MC1, Connell AM, Schachat AP, Hyman L. The Barbados Eye Study. Prevalence of open angle glaucoma. Arch Ophthalmol. 1994;112(6):821-9. 12. Rudnicka AR, Mt-Isa S, Owen CG, Cook DG, Ashby D. Variations in primary open-angle glaucoma prevalence by age, gender, and race: a Bayesian meta- analysis. Investigative ophthalmology & visual science. Invest Ophthalmol Vis Sci. 2006;47(10):4254- 61. 13. King AJ1, Reddy A, Thompson JR, Rosenthal AR. The rates of blindness and of partial sight registration in glaucoma patients. Eye(Lond). 2000:14(Pt 4):613-9. 14. Kaw SMG,Martinez JM, Tumbocon JA, Atienza NJ. Correlation of Average RNFL Thickness Using the STRATUS OCT with the Perimetric Staging of Glaucoma. Philipp J Ophthalmo 2012;37:19-23. 15. Caprioli J. Discrimination detween normal and glaucomatous eyes. Invest Ophthal Vis Sci. 1992;33:153-9. 16. Sihota R, Sony P, Gupta V et al. Diagnostic capability of optical coherence tomography in evaluating the degree of glaucomatous retinal nerve fiber damage. Invest Ophthalmol Vis Sci. 2006;47:2006-10. 17. Ajtony C, Balla Z, Somoskeoy S et al. Relationship between visual field sensitivity and nerve fiber layer thickness as measured by optical coherence tomography. Invest Ophthalmol Vis Sci. 2007;48: 258-63. 18. Horn FK, Mardin CY, Laemmer R et al. Correlation between local glaucomatous visual field defects and loss of nerve fiber layer thickness measured with polarimetry and spectral domain OCT. Invest Ophthalmol Vis Sci. 2009;50:1971-77. 19. Cvenkel B, Kontestabile AS. Correlation between nerve fibre layer thickness measured with spectral domain OCT and visual field in patients with differentstages of glaucoma. Graefes Arch Clin Exp Ophthalmol Apr. 2011;249(4):575-84. 20. Kaushik S, Singh PS, Ichhpujani P et al. Retinal nerve fiber layer measurement and diagnostic capability of spectral-domain versus time-domain optical coherence tomography. Eur J Ophthalmol. 2011; 21(5): 566-72. 21. Spaeth GL,hinderer J,liuC, Kesen M,Altangerel U, Bayer A,et al. Quigley HA, Katz J, Derick RJ, Gilbert D, SommerA. An evaluation of optic disc and nerve fiber layer examinations in monitoring progression of early glaucoma damage. Ophthalmology. 1992;99:19 28. 22. Kanamori A, Nagai-Kusuhara A, Escafio MFT, Maeda H, Nakamura M, Negi A. Comparison of confocal scanning laser ophthalmoscopy, scanning laser polarimetry and optical coherence tomography to discriminate ocular hypertension and glaucoma at an early stage. Graefes Arch Clin Exp Ophthalmol. 2006; 244: 58\u201368. 36. 23. Chauhan BC, Mikelberg FS, Balaszi AG, LeBlanc RP, Lesk MR, Trope GE et al. Canadian Glaucoma Study: 2. risk factors for the progression of open-angle glaucoma. Arch Ophthalmol. 2008;126:1030\u20136. 24. Quigley HA, Miller NR, George T. Clinical evaluation of nerve fiber layer atrophy as an indicator of glaucomatous optic nerve damage. Arch Ophthalmol. 1980;98(9):1564-71. 25. Sommer A, Katz J, Quigley HA, Miller NR, Robin AL, Kumar J & Shakya RK: Correlation Among Optic Nerve Head Changes People's Journal of Scientific Research January 2020; Volume 13, Issue 1 08 Richter RC, et al. Clinically detectable nerve fiber atrophy precedes the onset of glaucomatous field loss. Arch Ophthalmol. 1991;109(1):77-83. 26. Caprioli J, Miller J. Measurement of relative nerve fiber layer surface height in glaucoma. Ophthal- mology 1989;96(5):633 41. 27. Jonas JB, Fern\u00e1ndez MC, St\u00fcrmer J. Pattern of glaucomatous neuroretinal rim loss. Ophthalmology 1993;100(1):63-8. 28. Quigley HA, Dunkelberger GR, GreenWR. Retinal ganglion cell atrophy correlated with automated perimetry in human eyes with glaucoma. Am J Ophthalmol. 1989;107(5):453 64. DOI: https:// doi.org/10.1016/0002-9394(89)90488-1. 29. Strouthidis NG; Vinciotti V; Tucker AJ; Gardiner SK; Crabb DP; Garway-Heath DF. Structure and functional in glaucoma: the relationship between a functional visual field map and an anatomic retinal map.Inveat Ophthalmol Vis Sci 2006;47:5356-62. 30. Shah NN, Bowd C, Medeiros FA, Weinreb RN, Sample PA, Hoffmann EM, et al.: Combining structural and functional testing for detection of glaucoma. Ophthalmology. 2006113(9):1593-602. Cite this article as: Correlation Among Optic Nerve Head Changes, Visual Field Changes and Kumar J & Shakya RK: Retinal Nerve Fiber Layer Thickness in Primary Open Angle Glaucoma. PJSR ;2020:13(1):1-9. Source of Support : Nil, Conflict of Interest: None declared. Kumar J & Shakya RK: Correlation Among Optic Nerve Head Changes"]}

A prospective cross-sectional non interventional type of study was conducted among cases of primary open glaucoma (POAG).The purpose of the study was to understand correlation among optic nerve head changes, visual field changes and retinal nerve fiber layer thickness in cases of primary open angle glaucoma. This study, conducted among 72 patients with 138 eyes, established a positive correlation between mean vertical CDR (r 0.5726) as compared with mean RNFL thickness and a negative and weak positive correlation between mean vertical CDR compared to visual field parameter mean defect MD (r -0.2364) and PSD (r 0.3516) respectively. The p value between CDR and RNFL thickness was 0.00001, which was statistically significant.