Here we provide the human CollecTRI prior (accessed May 2023) for inference of TF activity across 31 GTEx tissues using multivariate linear modeling method decoupleR. The `human_prior_tri.csv` includes 1,178 unique TFs (referred to as the source) that target 6,627 unique genes (referred to as targets) to give us 42,595 interactions in the CollecTRI prior input. Interactions are represented as a + or - 1 (mor).