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Microenvironment of metastatic site reveals key predictors of PD-1 blockade response in renal cell carcinoma

Authors: Jeanneret, Florian; Bazelle, Pauline; Schoch, Sarah; Pillet, Catherine; Um, In Hwa; Bouzit, Assilah; Evrard, Bertrand; +15 Authors

Microenvironment of metastatic site reveals key predictors of PD-1 blockade response in renal cell carcinoma

Abstract

Immune checkpoint blockade (ICB) therapies are now an important tool in the arsenal for the treatment of advanced cancer extending progression-free survival and overall survival. However, only a subset of cancer patients responds to ICB therapies causing an urgent need for novel approaches to better select patients who may benefit from immunotherapy. Here, we used metastatic ccRCC samples obtained before ICB treatment and performed cell deconvolution analysis to investigate novel biomarkers of ICB treatment response.

Country
France
Keywords

[SDV]Life Sciences [q-bio], 610, [INFO.INFO-BI] Computer Science [cs]/Bioinformatics [q-bio.QM]

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selected citations
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This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
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Cancer Research