Background & Objectives: Objective of this study is to evaluate accuracy and predictability of PANC-3 over BISAP scoring system to predict severity in an attack of acute pancreatitis. Methods: A total of 160 cases were enrolled in the study and was conducted in Department of General Surgery, ESICMC & PGIMSR, Bangalore. All patients with clinical diagnosis of acute pancreatitis will be included in the study. It was a prospective study with study period of 18 months. Results: A total number of 160 patients were included in the study. Patients presenting with acute pancreatitis were maximum in age group of 31-40 years which included 60 patients (37.5). 153 (96%) patients were male and 4 percent (n=7) are female. Most common cause is alcohol- 124 (77.5%) patients. Next common cause is the gallstone 19 patients (11.9%). The most common chief complaint in our study was characteristic upper abdominal pain (100%) followed by vomiting (22.5%), fever (13.8%), jaundice (1.9%) and abdominal distension (1.3%). 91 patients were diagnosed to have mild acute pancreatitis, 37 patients with moderate acute pancreatitis and 32 patients with severe acute pancreatitis. All the 32 patients were correctly predicted by PANC-3 score. 11(6.9%) developed complications like pancreatic necrosis, pancreatic abscess, upper gastrointestinal bleeding, MODS, sepsis and death. 3 patients died due to complications associated with severe pancreatitis which accounts for 1.9%. Interpretation &Conclusion: Our study shows that PANC-3 can be used to predict the severity of pancreatitis as efficiently as BISAP scoring. It uses only 3 criteria which are easily done and available in even the basic health care setup. The interpretation of PANC-3 does not need expertise and can be applied at the time of admission which is an advantage when compared to classical scoring systems.