Among the different routes of administration, the oral route of administration continues to be the most preferred route due to various advantages including ease of ingestion, avoidance of pain, versatility and most importantly patient compliance. The different dosage forms include tablets and capsules. Recently immediate release tablets have started gaining popularity and acceptance as a drug delivery system, mainly because they are easy to administer and lead to better patient compliance. The present work involves the formulation development and in-vitro evaluation of immediate release Ambrisentan tablets. First Pre-formulation studies were carried out such as FTIR, bulk and tapped density, hounars ratio, Carr’s index, the angle of repose etc. Then the tablets were prepared by direct compression using super disintegrating agents (Kyron T-314, Sodium Starch Glycolate and Crospovidone). All formulation showed compliances with Pharmacopoeial standards. The study reveals that formulations prepared by direct compression F5 formulation exhibits highest dissolution using Sodium Starch Glycolate showed faster drug release 100.07 %. Key words: Ambrisentan, superdisintegrant, Kyron T-314, Sodium Starch Glycolate and Crospovidone and Immediate release tablet.