There are many drugs including both plant and mineral origin, which cannot be utilized directly. Even though those drugs are having high therapeutic value, they can be utilized only after following proper Sodhana. Sodhana has a very important role to reduce the toxicity or Teekshanatha of those drugs. But if those drugs are taken accidently or without following Sodhana, it will shows toxic reactions. Prathyoushadas are the drugs which used as antidote in such conditions. In Prayogasamucchaya, Prathyoushadas were explained in Ekadasha Paricchedam under the context of Asudha Bhakshana Chikitsa. Here author had explained Prathyoushada not only for Upavishas but also for some of the plant and mineral origin drugs if consumed without following Sodhana. Hence in this work an attempt is made to review the Prathyoushada explained in Prayogasamucchaya