In today’s world, information acquisition and communication has become easier utilizing various digital devices leading to huge rise in the usage of smartphones and computers among the younger population leading to postural abnormalities. However, little is known about musculoskeletal pain syndrome in Indian youth. The aim of this study was to find out the frequency of musculoskeletal symptoms associated with utilization of smartphones and other digital devices among college students in Mangaluru, Karnataka. Methods and Materials: This was an observational analytical preliminary study conducted using a validated questionnaire among 379 college students aged between 18-25 years. Students from various colleges were contacted and the questionnaire was distributed. Results: The usage of smartphones in college students in Mangaluru is 99%. Computer users were 77% and only 13% of individuals were using tablets. The study result shows that prolonged duration of smartphone usage is associated with increased frequency of neck, upper and lower back pain. Also, prolonged computer usage leads to upper back and shoulder pain whereas continuous tablet usage without changing position has been associated with arm pain. Conclusion: This study provides information about the influence of different digital device usage and its impact on the occurrence of musculoskeletal symptoms like neck, shoulder, upper/ lower back and arm pain in college students. Hence, it is a global concern to spread awareness of proper ergonomics and good posture while using various digital devices to prevent musculoskeletal pain or discomfort in youth.