Androgenetic alopecia (AGA) is a condition that affects both men and women with a genetic predisposition, causing a non-scarring reduction in the size of hair follicles.The underlying cause can be attributed to the enzyme 5-alpha-reductase, which converts testosterone into dihydrotestosterone (DHT). DHT, a potent androgen formed from testosterone by the action of 5-alpha-reductase enzymes, attaches to androgen receptors in susceptible hair follicles, leading to a decrease in size and eventually halting hair growth. The accumulation of DHT in hair follicles results in hair loss. The primary therapeutic approach for treating AGA revolves around inhibiting 5-alpha-reductase. Recently, there has been growing interest in the use of Allium cepa (onion) extract as a natural remedy for AGA. This study focuses on conducting in silico and ADME/T analyses of the active compounds found in onion extract to assess and visualize their interaction with 5-alpha-reductase protein.