Saliva as a diagnostic fluid offers distinctive advantages over serum because it is collected non- invasively by individuals with modest training. furthermore, saliva may provide an economical approach for the screening of huge populations. whole saliva could also be used for diagnosis of systemic diseases, because it contains serum constituents. Early detection plays a crucial role in its prevention and progression. saliva may be a reliable medium that mirrors periodontal health and is easily obtainable for identifying periodontal biomarkers in point-of-care diagnostics. This article review explains the periondontal applications of saliva and gingival crevicular fluid as a diagnostic tool. In future we are likely to ascertain the increased utilization of saliva as a diagnostic fluid.