In orthodontic treatment, mechanotherapy is needed to move the teeth. It is a challenge for the dentist to maximize the desired tooth movement without losing anchorage. Some experts have proposed a mechanical device to prevent the loss of anchorage, but it is still common to lose anchorage and cause side effects such as root resorption, white spots, caries, gingivitis and others. The use of bisphosphonates is recommended for the control of relapse and even for establishing pharmacological anchors. Bisphosphonates are pharmacological agents used to treat osteoporosis patients. This pharmacological agent is a potential bone resorption inhibitor. So, the use of bisphosphonates can be useful for orthodontist to control anchorage movement. Many literatures have begun to discuss the use of BP in orthodontic treatment patients. This review article aims to analyze the literature that discusses the influence of BP on orthodontic tooth movement.