In the present study, the anti-inflammatory and analgesic effect of the hydroalcoholic extract of coccinia grandis whole plant was investigated. The hydroalcoholic extracts of coccinia grandis whole plant were ingested orally (p.o.) in two different doses, 200 and 400 (mg/kg body weight). The anti-inflammatory effect of coccinia grandis was tested in: carrageenin-induced paw oedema in wistar albino rats and compared with the standard, diclofenac (10 mg/kg body weight). The analgesic effect of the hydroalcoholic extract of coccinia grandis was evaluated in Swiss albino mice by using Eddys hot plate method and compared with the standard, aspirin (25 mg/kg body weight). The results showed that coccinia grandis has significant reduction (p.0.01) in inflammation (200 mg/kg body weight) and (400 mg/kg body weight) as compared to the standard drug, diclofenac. In assessing analgesic effects, there is a significant (p<0.01) reduction in the paw licking for (400 mg/kg) and diclofenac (10 mg/kg) when compared to control. These results expressing that extracts would possess analgesic and anti-inflammatory properties. All these effects and changes in the behavioural activities in mice could be suggested as contributory effects to the use of coccinia grandis whole plant in the management of inflammation and painful conditions. Keywords: coccinia grandis , Anti-inflammatory, Analgesic, Indomethacin,