Image registration plays a vital role in understanding changes that occur in 2D and 3D scientific imaging datasets. Registration involves finding a spatial transformation that aligns one image to another by optimizing relevant image similarity metrics. In this paper, we introduce itk-elastix, a userfriendly Python wrapping of the mature elastix registration toolbox. The open-source tool supports rigid, affine, and B-spline deformable registration, making it versatile for various imaging datasets. By utilizing the modular design of itk-elastix, users can efficiently configure and compare different registration methods, and embed these in image analysis workflows. The current poster is presented in SciPy 2023 conference.