Skin infection have variable presentations, etiologies and severities. Among the numerous drug delivery systems, vesicles as a drug carrier system have emerged as the preferred vehicle. Transfersomes have been discovered to be one of the most effective drug-delivery methods for topical treatment when compared to conventional topical systems. So, in this study, with the use of a gelling agent as a vehicle for the inclusion of transfersomes the transferosomal gel of chrysin was created for topical administration system. Preparation & evaluation of transferosomal gel was performed as per standard method. Results showed that F-12 formulation have lowest vesicle size of 165.58% with & entrapment efficiency of 73.49%. The zeta potential for F12 was recorded as -38.85. Further, the result of evaluation of transferosomal gel suggested that the optimized gel OTGF1 have Extrudability (g) and Spreadability (g.cm/sec) as 185±2.5 g and 11.15±1.5 g.cm/sec respectively. The viscosity of gel was noted to be 3215±18 cps. The % assay for transferosomal gel was estimated to be 98.15±0.32%. The % Cumulative Drug Release was found to be 92.23 at 12hour. Also, the formulated transferosomal gel was found to be stable for 3 months at 4.0 ±0. 2°C with normal physical appearance & drug content of 95.58&%. Keywords: Skin infection, Topical drug deliver, Novel drug delivery system Transferosome, Transferososmal gel