Medicinal plants based traditional systems of medicines are playing an important role in providing healthcare to large section of population, especially in developing countries. Herbal medicines are the fundamental method adopted in traditional methods to cure various diseases and physiological conditions. They are Siddha, Ayurveda,Unani, Folklore, Ethanomedicine and Naturopathy. Some of the traditional medicines are still used by man for their habitual treatment for various diseases. Phyto-chemicals are non-nutritive plant chemicals that have protective or disease preventive properties. Phytochemicals are used for the prevention and treatment of many health conditions including cancer, heart disease, diabetes, blood pressure, kidney disease, psychiatric illness, skin disease and arthritis and high blood pressure. The most important of these bioactive constituents of plants are steroids, terpenoids, carotenoids, flavanoids, alkaloids, phenolic compounds, tannins and glycosides. Medicinal plant drug discovery continues to provide new and important leads against various pharmacological targets including cancer, HIV/AIDS, Alzheimer’s disease. List of Bio Medicines derived from plant sources were collected and searched in the published papers, research articles, text books and grey articles. In those more than 75 % are identified from the published papers and research articles. Remaining 25 % only obtained from text books and grey articles. Totally 123 bio-medicine compounds were identified from various plant sources, these compounds are used in many form of medicines in modern system as chemical entity. It is concluding that most of the bio medicine compounds were isolated or modified only from plant sources. The individual compounds may produce more adverse effects but the natural plant sources are very much less to produce complications when they are given in a appropriate doses.