Background: Cervical cancer is the most common malignancy and health problem in women of all sections of society. Cancer is a group of diseases characterized by the uncontrolled growth and spread of abnormal cells. Cervical cancer is the most common cause of death among women worldwide, with about 570, 000 cases and 311,000 deaths, despite the fact that cervical cancer is preventable. It ranks as the first most frequent cancer among women between 21 – 44 yr of age. Methods: A quantitative study was carried out in 35 adolescent girls and the non-probability purposive sampling technique was used for the selection of the subjects and the college. The data was collected through of using a structured knowledge questionnaire. A structured teaching program was developed and administered to the reproductive age girls (17-35 years). Results: The data were analyzed by using descriptive and inferential statistics. The result revealed that after the intervention the mean and standard deviation of the post-test knowledge was 17.65±2.11 being compared to mean and standard deviation of pre-test knowledge 7.2±2.35. The enhancement of knowledge score is the mean difference 10.54. It indicates that there was a significant improvement in the level of knowledge of participants. The calculated t- value (6.57) on analysis of the data was found to be significant at p value 0.05. Conclusions: The study concluded that a structured teaching programme was significant effective to improving the level of knowledge of cervical cancer.