file: GSEM_commonFactorGWAS_COPC_6trait_30MAY2023.csv.gz description: Common factor GWAS output for GenomicSEM analyses of 6 COPC traits (see doi: https://doi.org/10.1101/2023.06.27.23291959) columns: SNP = rsID SNP identifier CHR = chromosome BP = base pair position MAF = minor allele frequency A1 = effect allele A2 = other allele i = index (1 - n SNPs) lhs = left hand side of equation op = equation operator (lavaan syntax) rhs = right hand side of equation est = effect size (beta) se_c = standard error of effect estimate Z_Estimate = Z value Pval_Estimate = p value of effect Q = Q (heterogeneity) value Q_df = degrees of freedom for Q Q_pval = Q p value fail = GSEM fail message if applicable warning = GSEM warning message if applicable Z_smooth = smoothing parameter if applicable N_estimate = N estimate file: GSEM_commonFactorTWAS_COPC_6trait_30MAY2023.csv.gz description: Common factor TWAS output for GenomicSEM analyses of 6 COPC traits (see doi: https://doi.org/10.1101/2023.06.27.23291959) columns: Gene = ensembl gene ID Panel = which model (tissue+gene) i.e. reference weights file HSQ = gene heritability i = index (1 - n gene-tissue models) lhs = equation left hand side op = operator (lavaan syntax) rhs = equation right hand side est = association estimate (beta) se_c = standard error of beta Z_Estimate = Z value Pval_Estimate = p value of association test Q = Q (heterogeneity) value Q_df = degrees of freedom for Q Q_pval = p value for Q fail = GSEM fail message if applicable warning = GSEM warning message if applicable tissue = tissue p_bonf_tissue = adjusted p value - bonferroni adjustment within tissue p_fdr_tissue = adjusted p value - false discovery rate adjustment within tissue threshold_bonf_tissue = p value threshold for bonferroni adjustment within tissue p_bonf_experiment = adjusted p value - bonferroni adjustment experiment-wide p_threshold_bonf_experiment = p value threshold (bonferroni, experiment-wide) Q_bonf_tissue = adjusted p value for Q, bonferroni within-tissue

associated with doi: https://doi.org/10.1101/2023.06.27.23291959