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World Journal of Advanced Research and Reviews
Article . 2023 . Peer-reviewed
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Article . 2023
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Development and validation for the simultaneous estimation of olmesartan medoxomil and hydrochlorothiazide by using RP-HPLC methods

descriptionPublicationkeyboard_double_arrow_right Article 28 Feb 2023Publisher:GSC Online PressJournal:World Journal of Advanced Research and Reviews, volume 17, pages 686-696 (eissn: 2581-9615, Copyright policy )
Authors: Anumalagundam Srikanth; Govindarao Yedlapalli; G Srikanth; Gummalla Lakshmi Harathi; Singh Sarika Anil;

doi: 10.30574/wjarr.2023.17.2.0247 , 10.5281/zenodo.8109486 , 10.5281/zenodo.8109485

Development and validation for the simultaneous estimation of olmesartan medoxomil and hydrochlorothiazide by using RP-HPLC methods

Abstract

A simple, Accurate, precise method was developed for the simultaneous estimation of the Olmesartan Medoxomil and Hydrochlorothiazide in Tablet dosage form. Chromatogram was run through Inertsil -ODS C18,250 x 4.6 mm, 5m. Mobile phase containing Methanoland Bufferin the ratio of 80:20 was pumped through column at a flow rate of 10ml/min. Optimized wavelength for Olmesartan Medoxomil and Hydrochlorothiazidewas 260nm. Retention time of Olmesartan Medoxomiland Hydrochlorothiazide were found to be 3.270min and 4.566 min. %assay was obtained as 99.91% and 99.95% for Olmesartan Medoxomiland Hydrochlorothiazide respectively. Regression equation of Olmesartan Medoxomilis y = 30712x - 31891, and y = 16499x + 8683. Of Hydrochlorothiazide.

Keywords

Olmesartan Medoxomil; Hydrochlorothiazide; RP-HPLC; Validation; Simultaneous Estimation.

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selected citations
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This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
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