The dataset includes 430 collected answers from self-reported online distributed questionnaires regarding healthcare professionals views on e-prescription systems in Greece. The survey was conducted in the context of the PrescIT project (https://www.prescit.com/), aiming to elicit end-user requirements for the developed PrescIT e-prescription and clinical decision support platform. The dataset is currently available in the Greek language. Results from the analysis of the dataset have been presented in the following publication: - Grammatikopoulou, M., Lazarou, I., Giannios, G., Kakalou, C.A., Zachariadou, M., Zande, M., Karanikas, H., Thireos, E., Stavropoulos, T.G., Natsiavas, P., Nikolopoulos, S., Kompatsiaris, I., Electronic prescription systems in Greece: a large-scale survey of healthcare professionals’ perceptions. Arch Public Health 82, 68 (2024). https://doi.org/10.1186/s13690-024-01304-6