The aim of the study was to try to determine the influence of gender characteristics, age, and seniority on the intention to leave the business of insurance agents. Through the qualitative research method, the research team presented an overview and theoretical basis for the intention to leave the enterprise. There are many factors affecting the intention to leave that have been studied by other authors, so we focus on the less-mentioned content, which is the assessment of the difference in gender, age, and seniority intention to leave the business. With 240 agents participating in the survey, the research team obtained primary data for Independent T-Test and One-Way ANOVA analysis. The results of data analysis show that the factors of gender, age, and seniority have statistically significant differences and affect the intention to leave the business of insurance agents. This research result is also the basis for life insurance enterprises in Vietnam to have plans to improve their personnel retention policy.