The paper examined relationship between information technology and entrepreneurship success in Bayelsa State. Specifically, the study is to examine the relationship between information technology and SMEs success in Bayelsa State, and the challenges of adopting information technology for entrepreneurship success in Bayelsa State. This paper adopted the quantitative research approach and adopting cross-sectional survey design which involve multiple SMEs in Bayelsa State. Population for this study consist of fifty (50) entrepreneurs in Bayelsa state. A self-designed questionnaire was modified and adopted as the instrument of primary data collection, which was previously used by Olusegun (2015), with an overall reliability coefficient of 0.64 for all question items in the Likert-5 response scale instrument. Data collected was analyzed adopting descriptive analysis for the socio-economic data and Pearson Moment Correlational Coefficient as the inferential analysis. The result shows that there is an empirical link between information technology and SMEs success in Bayelsa State, and there are visible challenges in adopting information technology for entrepreneurship success in Bayelsa State. In Conclusion, the use of information technology to small business operations has had a significant positive influence on entrepreneurial practices from the viewpoints of SMEs in Bayelsa State, Nigeria. The paper recommended that the government need to provide entrepreneurs sufficient funding so that they may employ modern technologies in their small businesses, which will help them expand.