{"references": ["1.\tHiremath, G., & Kamat, D. (2015). Diagnostic considerations in infants and children with cyanosis. Pediatric annals, 44(2), 76-80.", "2.\tMcMullen, S. M., & Patrick, W. (2013). Cyanosis. The American journal of medicine, 126(3), 210-212.", "3.\tTaleb, M., Ashraf, Z., Valavoor, S., & Tinkel, J. (2013). Evaluation and management of acquired methemoglobinemia associated with topical benzocaine use. American Journal of Cardiovascular Drugs, 13, 325-330.", "4.\tLundsgaard, C. (1919). STUDIES ON CYANOSIS: II. Secondary Causes of Cyanosis. The Journal of Experimental Medicine, 30(3), 271-293.", "5.\tLundsgaard, C. (1919). STUDIES ON CYANOSIS: I. Primary Causes of Cyanosis. The Journal of Experimental Medicine, 30(3), 259-269.", "6.\tDantzker, D. R., Foresman, B., & Gutierrez, G. (1991). Oxygen supply and utilization relationships: a reevaluation. American Review of Respiratory Disease, 143(3), 675-679.", "7.\tLees, M. H. (1970). Cyanosis of the newborn infant: recognition and clinical evaluation. The Journal of pediatrics, 77(3), 484-498.", "8.\tLees, M. H., & King, D. H. (1987). Cyanosis in the newborn. Pediatrics in Review, 9(2), 36-42.", "9.\tSteinhorn, R. H. (2008). Evaluation and management of the cyanotic neonate. Clinical pediatric emergency medicine, 9(3), 169-175.", "10.\tRalston, A. C., Webb, R. K., & Runciman, W. B. (1991). Potential errors in pulse oximetry III: effects of interference, dyes, dyshaemoglobins and other pigments. Anaesthesia, 46(4), 291-295."]}

Bluish coloration of skin as well as mucus membrane. Cyanosis is particularly seen in many areas where the skin exhibits very thinness. Cyanosis is not seen in anemic hypoxia because the hemoglobin content itself is very low. Cyanosis does not occur particularly in histototocic hypoxia because of tissue damage also. In polycythemia, the quantity of deoxygenated blood enhances which results in the bluish discoloration of skin. Particularly, if the level of deoxygenated hemoglobin is approximately, 3-5 g/dl, cyanosis happens to the maximum extent. In most of the conditions, the cardiac pulmonary system is related to the development of cyanosis. Normally, abnormal hemoglobin is not accepted by the pulse oximetry and that is why, particularly in methemoglobiunemia, the pulse oximetry reading shows more value in a wrong way. Cyanosis is divided into peripheral cyanosis and central cyanosis. Treatment of central cyanosis requires correction of metabolic abnormalities, different types of drugs such as ACE inhibitors and di-uretcs and oxygen therapy. Differential diagnosis is linked to anemia, heart failure, hydrocarbon toxicity, metabolic acidosis, pulmonary embolism and rota virus.