The main focus of this research study was to develop a effective face serum using salicylic acid and ascorbic acid. Four formulations where each contains 2% w/w salicylic acid and 2% w/w ascorbic acid with varying concentration of another excipients. The prepared face serum were examined visually, pH, viscosity, globule size determination, spreadability, homogeneity and after feel. Upon evaluation, the Formulation F4 showed ideal suitable pH to the skin and globule size. Through this research work we intend to show safe and effective face serum and proven to be effective as anti pigmentation and anti acne. Salicylic acid is well-known for its effectiveness in treating acne. It works by exfoliating the skin, unclogging pores, and reducing the formation of acne-causing bacteria. Ascorbic acid acts as antioxidant protection helps in collagen production, anti pigmentation (brightening and even skin tone), sun damage protection and anti-inflammatory effects. Our prepared face serum is suitable for skin care purposes. Key words: salicylic acid, ascorbic acid, Anti-pigmentation, Anti-acne.