Tuberculosis is a contagious disease caused by mycobacterium tuberculosis, leading to increased mortality and morbidity. Although many new diagnostic tests and treatments have emerged for TB, there is still a big question as to why it is not ending. The disease roots easily due to many confounding factors such as patient noncompliance, development of ADR during treatment and the evolution of drug resistance. The drugs used in treatment have a higher proportion of side effects. The majority patients required treatment modification due to ADRs. The proper identification, reporting, management, or prevention can increase compliance and positive outcomes of therapy. Keywords: Tuberculosis, Tuberculosis Treatment, Tuberculosis drugs, ADR management, Drug-resistant Tuberculosis.