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Several major developments have changed the field of orthodontics in the recent years. Digital imaging and computers have improved the diagnostic process. The introduction of prescription brackets, bonding, NiTi and other alloy wires have improved the treatment efficiency and efficacy. The paradigm shift in orthodontics arrived with the introduction of Aligner System. It allows both dental practitioner and patient to develop a visual understanding of orthodontic tooth movement. The esthetic and practical advantages of the system have extended orthodontic services to a greater population. This current review is to highlight the knowledge and application of clear aligners in not just simple but complicated malocclusion too, which is only possible with theoretical knowledge.