interTwin co-designs and implements the prototype of an interdisciplinary Digital Twin Engine (DTE). The developed DTE will be an open source platform that includes software components for modelling and simulation to integrate application-specific Digital Twins. InterTwin WP7 will provide the aforementioned sets of software components, called thematic modules, for the use cases defined in WP4. The current document consists of a report on the high-level description of the physics domain use cases and of the related designed thematic modules. Additionally, this deliverable includes the set of common requirements derived from the analysis of the use cases and thematic modules that will need to be available in the DTE core modules, designed in WP6.