Additional data from the manuscript "Mutational topography reflects clinical neuroblastoma heterogeneity" by Rodriguez-Fos, E et al. All the information required to support the conclusions reported in this manuscript is available in this dataset, including variant calling, mutational signatures activities, reconstruction of complex rearrangements, and unsupervised clustering results. Additional Data 1. Variant calling results from discovery and validation neuroblastoma cohorts. Additional Data 2. Mutational signatures analysis in the discovery and validation cohorts. Additional Data 3. Complex rearrangements analysis in the discovery cohort. Additional Data 4. Unsupervised clustering analysis in the discovery cohort. Additional Data 5. HRR deficiency and driver genes alterations analysis in the discovery cohort. Additional Figure 1. Evaluation of the ranks for the de novo signature extraction for SNV- and SV-based signatures in the validation cohort.