{"references": ["Bouaud, J., S\u00e9roussi, B., 2011. Revisiting the EBM decision model to formalize non-compliance with computerized CPGs: results in the management of breast cancer with OncoDoc2. AMIA. Annu. Symp. Proc. 2011, 125\u2013134.", "W\u00f6ckel, A., Kurzeder, C., Geyer, V., Novasphenny, I., Wolters, R., Wischnewsky, M., Kreienberg, R., Varga, D., 2010. Effects of guideline adherence in primary breast cancer--a 5-year multi-center cohort study of 3976 patients. Breast Edinb. Scotl. 19, 120\u2013127.", "Lieber, J., d'Aquin, M., Badra, F., Napoli, A., 2008. Modeling adaptation of breast cancer treatment decision protocols in the Kasimir project. Appl. Intell. 28, 261\u2013 274."]}

In this paper we present a novel method to build a CDSS that, besides integrating CIGs, stores experts’ knowledge to enrich the CDSS and provide best support to clinicians. The knowledge includes new evidence collected over time by the systematic usage of CDSSs.