Self-medication refers to the practice of treating oneself with medication without consulting a healthcare professional. This practice can be dangerous to health. This study aimed to assess the practice of self-medications and associated factors among students in Taiba University, Saudi Arabia. Across sectional study was employed to investigate the practice of self-medications among 210 students in Taiba University by using a self-administered questionnaire.Among all respondents, 87.1% practiced self-medication at least one medication in the last year. The most common self-medication was pain killers (80%) and the most common indication of use was headache (75%). Reasons of self-medication practices were previous experience (52.9%) and no serious health symptoms (51.0%). The most common source of information was personal knowledge (51.0%). The prevalence of elf-medication practice was 87.1%. The most common self-medication was pain killers while, the most common indication of self-medication was headache. The most common reason for self-medication practices was previous experience, and the most common source of information was personal knowledge. Males practiced self-medications more than females.