In the course of the second wave of COVID-19 in India,the nation witnessed a rapid surge of a deadly fungal infection leading to increased morbidity and mortality. The treatment of the mycosis necessitates timely and often invasive surgical debridement leading to the creation of acquired defects. With the maxillofacial region being a highly common area for the mycosis to occur the role of maxillofacial prosthodontists and surgeons becomes significant. This article elaborates on one such case of maxillary defect treated, restored and rehabilitated to almost life-like functionality (speech, mastication), appearance and efficiency by means of a definitive prosthesis. Through this article we highlight that the prosthodontic treatment does not end with the provision of a temporary solution but to continue with the maintenance to aid in substantial tissue healing and to meet demands of function and aesthetics.