AbstractLarge block‐bounding faults on the Tibetan plateau are significant geological structures that accommodate tectonic movements and accumulate stress, leading to large earthquakes. Quantifying the interseismic slip deficit rate helps to better assess the earthquake potential. We combine available InSAR (2015–2020) and interseismic GPS data to determine fault coupling along 14 major block‐bounding faults. Spatially dense InSAR measurements remarkably improve the resolution of the coupling model. Combined with a GPS‐constrained block model, we examine the performance of the inversion approach with the stress constraint and the common Laplacian smoothing based on both synthetic tests and real data. We suggest that, for continental strike‐slip faults, adding the stress constraint can mitigate unphysical coupling distributions due to unreasonable assumptions or modeling artifacts, reducing the model uncertainty and improving the accuracy of the coupling model. This is particularly useful for segments featured by a highly heterogeneous distribution of coupling along the transition zone from locking to creeping region, partially‐coupling segment, and junction zone between main and subsidiary faults. We present a large‐scale fault coupling map along the major block‐bounding faults on the northeastern and eastern Tibetan plateau, highlighting the distinct degrees of fault coupling and lateral variations. The collage of coupling maps along different faults demonstrates the kinematic features over a broad time scale during earthquake cycles ranging from early to late interseismic phases, such as the segments ruptured during the 2001 Kokoxili earthquake and the 1920 Haiyuan earthquake.