Major complication of hyperlipidemia are atherosclerotic heart disease, heart attack and heart stroke, but atherosclerosis is primary cause of death. Developing countries are reliant on medicinal plants as their main source of treatment for diseases. As Sesbania grandiflora have the native habitat the production is more so it is locally available cost effective with no side effects. As Sesbania grandiflora is cost effective and beneficiary in metabolism of cholesterol, so it has been taken in to consideration in order “To evaluate Anti-hyperlipidemic activity of Methanolic Extracts of Sesbania grandiflora in triton X -100 induced hyperlipidemic rats of the respective extracts. And the final results showed that this plant shows the hyperlipidemic activity and also shows minimal side effects towards the liver and cardiac muscle tissues. Key words: Sesbania grandiflora, hyperlipidemic activity etc.