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Surgical Menopause: Are we Pushing Women Towards the Menace of Accelerated Aging and Diseases?

Authors: Dr Ruchi Karla;

Surgical Menopause: Are we Pushing Women Towards the Menace of Accelerated Aging and Diseases?

Abstract

{"references": ["1. Smita S. Patne, Aditi J. Upadhye, Jayshree J. Upadhye. Surgical Menopause : Its Effect on Ovarian function and Menopausal symptoms . Analysis of indications and route of hysterectomy for benign conditions.Int J Reprod Contracept Obstet Gynecol. 2018;7(6):2347- 50.", "2. Sapna Desai, Oona MR Campbell,Tara Sinha,2 Ajay Mahal,Simon Cousens. Incidence and determinants of hysterectomy in a low-income setting in Gujarat, India. Health Policy and Planning. 2017;32:68\u201378. doi: 10.1093/heapol/czw099", "3. Ranjan Kumar Prusty , Chetan Choithani , Shiv Dutt Gupta. Predictors of hysterectomy among marriedwomen 15\u201349 years in India. Reproductive Health.2018;15:3. 15:3DOI 10.1186/s12978-017- 0445-8", "4. Michael R. Soulesa , Sherry Sherman , Estella Parrott, Robert Rebar, Nanette Santoro, Wulf Utian, and Nancy Woods. Executive summary: Stages of Reproductive Aging Workshop (STRAW). Fertility And Sterility. 2001;76(5):874-78.", "5. Jaff NG, Synman T, Norris SA, Crowther NJ. Staging Reproductive aging using stages of reproductive aging workshop +10 in black urban african women in the study of women entering and in endocrine transition. Menopause .2014;21(11)1225-33. doi:10.1097/ GME.0000000000000235.", "6. Patricia G, Moorman, Evan R, Myers, Joellen M. Schildkraut Edwin S, et al. Effect Of Hysterectomy With Ovarian Preservation On Ovarian Function. Obstet Gynecol. 2011;118(6):1271\u20131279. doi: 10. 1097/ AOG. 0b013e318236fd12.", "7. Emanuel C, Trabuco, Patricia G. Moorman, Alicia Algeciras-Schimnich, et al. Association of Ovary- Sparing Hysterectomy With Ovarian ReserveObstet Gynecol. 2016;127(5):819\u2013827. doi:10.1097/AOG. 0000000000001398", "8. Muttukrishna S, Sharma S, Barlow DH, Ledger W, Groome N, Sathanandan M. Serum inhibins, estradiol, progesterone and FSH in surgical menopause: a demonstration of ovarian pituitary feedback loop in women. Human Reproduction. 2002;17(10): pp.2535\u20132539.", "9. William H, Parker, Feskanich D, Michael S, Broder E, et al. Long-term Mortality Associated with Oophorectomy versus Ovarian Conservation in the Nurses' Health Study. Obstet Gynecol. 2013;121(4): 709\u2013716. doi:10.1097/AOG.0b013e3182864350.", "10. Abbas SZ, Vijayata Sangawan, Asim Das, and Anil Kumar Pandey.Assessment of Cardiovascular Risk in Natural and Surgical Menopause.Indian J Endocrinol Metab. 2018;22(2):223\u2013228.doi: 10.4103/ijem.IJEM_620_17", "11. Walter A. Rocca, Liliana Gazzuola Rocca, Carin Y. Smith, Brandon R. Grossardt, Stephanie S. Faubion, Lynne T. Shuster, James L. Kirkland, Elizabeth A. Stewart , Virginia M. Miller. Bilateral Oophorectomy and Accelerated Aging: Cause or Effect?. J Gerontol A Biol Sci Med Sci, 2017;72(9): 1213\u20131217. doi:10.1093/gerona/glx026", "12. Meeta, Leela Digumarti, Neelam Agarwal, Nirmala Vaze, Rashmi Shah, Sonia Malik Indian Menopause Society.Clinical practice guidelines on menopause: An executive summary and recommendations. 2013:4(2):77-106.http://www.j midlifehealth. org/text.asp?2013/4/2/77/115290 visited site on 30may 2019."]}

It is a routine practice among gynecologists and general practitioners to recommend hysterectomies for benign gynecological diseases. This article is challenging this practice. I) Natural menopause: The reproductive life is divided into 5 stages showing the transition of reproductive function. Discussed the stages of normal reproductive aging in women based on (STRAW +10) 2014.The average age of Menopause is 51 years. Menopausal transitional symptoms occur few years before final natural menopause as changes in the pattern of menstrual cycle, vasomotor hot flushes, night sweats, sleep disturbances, psychological and mental disturbances, somatic symptoms headache, dizziness, palpitations ii) Surgical Menopause: Surgical menopause causes severe symptoms due to the sudden fall of estrogen, progesterone, and ovarian androgen. Though ovarian failure develops in 2-5 years after surgery hormone deficiency occurs immediately and symptoms can occur as early as 24-48 hrs. iii) Ovarian function after hysterectomy done at a pre-menopausal age: Most likely causes of premature ovarian failure after Hysterectomy where ovaries are conserved a)Interference with ovarian blood supply at the time of surgery. b) Disturbance of Endometrial ovarian relationship c) Deficiency of Uterine Prostaglandins d) Loss of putative reflex pathway from the cervix to the pituitary. iv) The appearance of menopausal symptoms. v) Difference between Natural Menopause and Surgical Menopause: Surgical menopause with bilateral oophorectomy increases morbidity and is linked to accelerated aging. vi) Recommendation for AUB management for benign gynecological disease: Therapeutic Indications of Hysterectomy can be narrowed down to a few life-threatening indications of the ovary, uterus, and cervical malignancies. Prophylactic oophorectomy is done in high-risk BRCA - positive patients.

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Keywords

Surgical Menopause,, Ovarian function after hysterectomy done at a premenopausal age,, Natural menopause,

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