The oral cavity is part of the digestive system, which is composed of many important anatomical structures, including teeth, periodontal tissues, oral mucosa, maxillary and mandibular bones, as well as other soft and hard tissues. It is also a complex ecological niche as more than 700 microorganism species colonize the oral cavity, which is closely associated with oral health . The oral microbiota could help prevent pathogenic microorganisms from growing and help to maintain the stability and balance of oral microecology. However, the composition of oral microbiota could alter due to the change of diet, poor oral hygiene, systemic diseases, etc., which might lead to the dysbiosis of oral microecology, and thus many oral microbiota related diseases, i.e., oral infectious diseases. It has been widely considered that oral infectious diseases such as dental caries, periodontitis, peri-implantitis, and oral candidiasis are caused by microbial dysbiosis instead of specific kinds of bacteria. Furthermore, it has been gradually recognized that oral health is closely related to systemic health. Therefore, great effort has been made for the treatment and prevention of oral infectious diseases. Drug therapy plays an important role in the inhibition of bacterial growth and inflammatory response, and thus the promotion of tissue regeneration. Systemic administration and local drug delivery are both important ways for drug administration. However, systemic administration could cause many other problems. Keywords: Dental Caries, Oral Lesion, Gingivitis, Chewing Tablets.