Methylation haplotypes of the insulin gene promoter in children and adolescents with type 1 diabetes: could a dimensionality reduction approach predict the disease?

Name: Methylation haplotypes of the insulin gene promoter in children and adolescents with type 1 diabetes: could a dimensionality reduction approach predict the disease?
Creator: Eleni P Kotanidou, Alexandra Kosvyra
Keywords: children, adolescents, type 1 diabetes, insulin gene, epigenetics, CpG, methylation, 3. Good health

Eleni P Kotanidou, Alexandra Kosvyra

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ZENODO

Dataset . 2023

License: CC BY

Data sources: Datacite

ZENODO

Dataset . 2023

License: CC BY

Data sources: Datacite

Methylation haplotypes of the insulin gene promoter in children and adolescents with type 1 diabetes: could a dimensionality reduction approach predict the disease?

Research datakeyboard_double_arrow_right Dataset 03 Jun 2023Publisher:Zenodo

Authors: Eleni P Kotanidou, Alexandra Kosvyra;

doi: 10.5281/zenodo.8001833 , 10.5281/zenodo.8001832

Methylation haplotypes of the insulin gene promoter in children and adolescents with type 1 diabetes: could a dimensionality reduction approach predict the disease?

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Abstract

The aim of the present study was to identify insulin gene promoter (IGP) methyl-haplotypes among children and adolescents with T1D and suggest a predictive model for the discrimination of cases and controls according to methyl-haplotypes. Fourty individuals (20 T1D) participated. IGP-region from peripheral whole blood DNA of 40 participants (20 T1D) was sequenced by next generation sequencing, sequences were read using FASTQ files, and methylation status was calculated by python-based pipeline for targeted deep bisulfite sequenced amplicons (ampliMethProfiler). Methylation profile at 10 CpG sites proximal to transcription start site of the IGP was recorded and coded as 0 for unmethylation or 1 for methylation. A single read could result in “1111111111” methyl-haplotype (all methylated), “000000000” methyl-haplotype (all unmethylated) or any other combination.

Related Organizations

Aristotle University of Thessaloniki
Greece

Keywords

children, adolescents, type 1 diabetes, insulin gene, epigenetics, CpG, methylation

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