Background: Hematological abnormalities are common finding in Chronic Liver Diseaese(CLD). This study is conducted to assess the hematological abnormalities and Hemostatic derangements in CLD patients.Broadly, Hematological abnormalities are viewed under abnormalities in RBCS,WBCS, Platelets and Coagulation profile. Objectives: To study Hematological abnormalities in Chronic Liver Disease patients. Methods: I performed a cross sectional observation study in which 106 Chronic Liver Disease have been studied from November 2021 to November 2022 ,in KR Hospital Mysuru, Karnataka. SPSS software was used for statistical analysis of the data and P value less than 0.05 was considered significant Results:102 males and 4 females were enrolled in this study.Mean age group among males was 50.97 years and females was 52 years. Mean Hemoglobin in male subjects was 10.17g/dl and female subjects was 8.63g/dl. Mean platelet count in males was 103411c/microL and females was 85000c/microL. Normocytic anemia is majorly prevalent across both gender groups than Macrocytic. Majority of the study population has mild to moderate anemia. No significant variation in WBC count was noted.Vast majority had deranged coagulation cascade(prolonged PT -94.34%,aPTT- 81%).Thrombocytopenia is found in 86% of population majority (50%) had counts less than 1 lac. Conclusion: One or More hematological abnormality is noted in many Chronic Liver Disease(CLD) patients. Every CLD patient should be evaluated for hematological abnormalities and treated accordingly.