This study examined the causes and effects of climate change on buildings with a view to adopting the green Building Concept being a response strategy to mitigate the effects of climate change on buildings. Extensive review of literature and mixed method/approach were adopted to obtain data for the study. Questionnaire was used to elicit data for the study. 300 was the sample size for the study. Data analysis was done using statistical tools such as percentiles, mean score, Cochran return sample size formulae and the Analysis OF Variance (ANOVA) used for the tests of hypotheses. The findings of the study revealed that there is significant effects of climate change on buildings in the study area and that Green building concept is beneficial in mitigating the effects of climate change on buildings. The benefits derivable from adopting the green building concept in mitigating the effects of climate change on buildings and the dwellers were identified. These benefits include social, cultural, Energy conservation and improved Indoor air for comfortable living. The study therefore recommends continuous enlightenment of the public on the need to embrace green practices, while government should create a Green Building Assessment Unit in the Urban and Planning Department of Ministries of Works and Housing to promote, and monitor the implementation and enforcement of green practices in Ondo State (the study area) and should also grant incentives to home owners in form of rebates on tenement payments to encourage embracing green practices among others.