The study discusses futures of the plasma lipid profile (total cholesterol, triglycerides, low density lipoproteins, high density lipoproteins) and the peculiarities of their changes dynamic’s in patients with chronic pancreatitis and hypothyroidism comorbidity. The study of these pathologies comorbidity is rather promising area of clinical gastroenterology and endocrinology. Study revealed the most pronounced signs of dyslipidaemia in the group of patients with chronic pancreatitis and hypothyroidism. It confirms close pathogenetic relationship between these pathologies and requires further correction of treatment. Results indicates more comprehensive study of the course and interactions of these diseases in order to avoid complications and disability are needed.