The deposition contains data sets of human and mouse protein kinase inhibitors with reliable activity measurements and corresponding compounds classified as inactive that were assembled from public repositories. The human protein kinase inhibitors have recently been analyzed in detail [Xerxa et al., Data-Driven Global Assessment of Protein Kinase Inhibitors with Emphasis on Covalent Compounds. J Med Chem, 2023, in press, https://doi.org/10.1021/acs.jmedchem.3c00621].