The file is the trained convolutional neural network (CNN) developed in "Ugolini F et al.Tumor infiltrating lymphocytes recognition in primary melanoma by deep learning convolutional neural network" submitted to American Journal of Pathology (2023). The CNN is based on a a pre-trained Inception-ResNet-v2 to automatically to recognize areas in the tumor region containing TILs and area without TILs in histopathological digitalized slides of primary melanoma. The file is in a Matlab format (.mat).