The data included in this record constituted the input for the case study reported in the manuscript "DREAM: an R package for druggability evaluation of human complex diseases", by Antonio Federico, Michele Fratello, Alisa Pavel, Lena Möbus, Giusy del Giudice, Angela Serra, Dario Greco. The data derive from transcriptomics experiments executed on lesional skin from atopic dermatitis patients and unaffected skin counterparts. The data consists of two files in ".txt" format reporting gene expression data in tabular format, where on the rows are reported genes and on the columns are reported samples. The data is an aggregated and batch-corrected collection of datasets originally downloaded by Gene Expression Omnibus (GEO, https://www.ncbi.nlm.nih.gov/geo/). The file "GE_Mic_AD_Pamr_MAARS.txt" reports gene expression estimates of lesional skin of atopic dermatitis patients, while the file "GE_Mic_AD_Pamr_nl_MAARS.txt" reports gene expression estimates of non-lesional skin of atopic dermatitis patients.