Novel titrimetric method for the determination of rosuvastatin in pure form

descriptionPublicationkeyboard_double_arrow_right Article 28 Feb 2023Publisher:GSC Online PressJournal:World Journal of Biology Pharmacy and Health Sciences, volume 13, pages 1-4 (eissn: 2582-5542,

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Authors: Bhavya Sri Khagga; Srija Ghanukota; Sumakanth Mogili;

doi: 10.30574/wjbphs.2023.13.2.0054 , 10.5281/zenodo.7948477 , 10.5281/zenodo.7948476

Novel titrimetric method for the determination of rosuvastatin in pure form

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Abstract

In this experiment assay of Rosuvastatin was performed by titrimetric method. The titration performed is a complexometric titration. The complexometric titration used is an easy, inexpensive volumetric titration method. This method is based on rection of calcium with a solution of disodium ethylenediaminotetraacetate (EDTA). Complex of calcium and EDTA is formed. Erichrome black Tis used as an indicator in this complexometric titration. At pH 12-13, Erichrome black T changes the color from pink to blue. The appearance blue color is determined to be the endpoint of this experiment. The titrations were carried out in triplicates and the average reading was taken to calculate the percentage assay. The percentage purity was found to be 103.05%

Keywords

Complexometric Titration; Percentage Assay; Rosuvastatin; EDTA; Erichrome Black-T

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