Cancer-related wounds are still one of the healing challenges that are still faced by various health practitioners, where these wounds are often unsightly and associated with foul odor, drainage, and bleeding. Wounds caused by malignant tumors have a wide range of symptoms and severity, thus there is no treatment that has been demonstrated to be able to relieve them effectively. The use of wound dressings, which have antibacterial advantages and are helpful for treating wound infections as well as preventing wound contamination, is one method of wound care. Natural substances known as polyphenols, which are often created by plants, have potential antibacterial and antioxidant properties. G-90 is a mixed macromolecular substance with glyco-lipoprotein properties that aids in tissue regeneration in vivo, particularly when it comes to wound healing. Plenty of flavonoids are present in the polyphenolic chemicals produced by necklace worms (Pheretima aspergillum). Flavonoids contribute to the formation of cross-links with collagen, which can have the impact of accelerating wound healing and the decline in inflammatory cells like macrophages. In this situation, Pheretima aspergillum, which has G-90 glyco-lipoproteins and polyphenols, may be useful for healing malignant wounds.