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This work was supported by The Francis Crick Institute which receives its core funding from Cancer Research UK (CC001999), the UK Medical Research Council (CC001999), and the Wellcome Trust (CC001999). D.K. was funded by The Francis Crick Institute and the Pasteur-Paris University International doctoral program (PPU). R.F.L. was supported by a Medical Research Council Skills development fellowship (MR/T027924/1). R.H. is supported by the Gulbenkian Foundation (Fundação Calouste Gulbenkian) and received funding from the European Research Council (ERC) under the European Union's Horizon 2020 research and innovation program (grant agreement number 101001332), the European Molecular Biology Organization (EMBO) Installation Grant (EMBO-2020-IG4734) and the Chan Zuckerberg Initiative Visual Proteomics Grant (vpi-0000000044). Matt Russell (Electron Microscopy Science Technology Platform, The Francis Crick Institute and Centre for Ultrastructural Imaging, King's College London) collected preliminary CLEM data used in testing.
Sample volume electron microscopy dataset cropped from EMPIAR-10819 and fluorescence dataset from BioImage Archive S-BSST707 for the CLEM-Reg paper.
electron microscopy, deep learning, alignment, fluorescence microscopy
electron microscopy, deep learning, alignment, fluorescence microscopy
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