This study evaluates the chronic wasting disease research output from 1990–2021. We have made a scientometric analysis of contributions to peer-reviewed journals and international collaboration publications. Most productive authors, most productive institutions, and most cited research papers. The study uses 31 years (1990–2021) of publication data in chronic wasting disease research from the Web of Science international multidisciplinary bibliographical database. Chronic wasting disease research shared 1384 publications in collaboration with 53 countries and registered 37940 citations. There were 1384 research articles published in 409 journals, with 962 authors representing 1648 institutions. The most collaborative countries: The United States has the most collaboration records with 876, followed by Canada with 228 and the UK with 139. The most productive authors are "Miller MW," which has a 6549 global citation score with 100 publications, followed by "Hoover EA," which has a 3216 global citation score with 82 publications, and "Telling GC," which has a 2619 global citation score with 62 publications. The most preferred journals were "PRION," which has 1034 citations with 159 publications, followed by "PLOS One," which has 2021 citations with 79 publications, and "Journal of Virology," which has 2274 citations with 53 publications.