The qualitative distinctions in adaptive physiological biochemical response reactions of pumpkin plants to heavy metals of different nature under salinity conditions were shown on the example of dynamics of growth, accumulation of various forms of nitrogen and activities of proteolytic enzymes. It was confirmed that plant responses to combined action of toxicants depend on species of plants and their belonging to concrete ecological groups. Data showed the low species-specific tolerance of Cucurbita pepo L. belonging to glycophites, to copper and its noticeable resistance to lead and nickel under conditions of salinity.