The paper considers geophysical monitoring observations on magnetic variations, on changes in the substance of subsoil radon on the territory of Garni Geophysical Observatory (GGO), on the seismic regime of the polygon, on the geochemistry of fresh spring water and water of mineral springs located in central Armenia (2010). The results of geophysical observations, the data of the chemical analysis of water, were compared with the seismic regime of the region and the accompanying geodynamic movements of the Earth's crust. In order to assess the stress-strain state of the Earth's crust in the seismically active region of Armenia, maps of isolines of equal values of deformation were developed according to the water levels of hydrogeodynamic boreholes in the region, reflecting the geodynamic movements of the Earth's crust in the form of local stress points (compression or tension).