Background: The tissue engineering technique to bone and periodontal tissue regeneration therapy that makes use of one or more of three key factors: signaling molecules, scaffold or supporting matrix, and cells. The graft works as a scaffold and a framework for forming a structure to aid tissue regeneration. One of the most generally used graft substances is hydroxyapatite (HAp). Hydroxyapatite (HAp) is a calcium phosphate derivative that is commonly utilized in bone coatings and cements due to its exceptional biocompatibility. The topic of nano- hydroxyapatite (nHAp) in tissue regeneration therapy will be discussed in this publication. Methods: The method used in writing this article review was a literature review sourced from Google Scholar, Science Direct, and PubMed (MEDLINE). Result: The identification results from a search on Google Scholar, Science Direct, and PubMed (MEDLINE) in which the title contains one or more keywords being searched for, from the article, 55 articles are obtained that have appropriate titles and 14 data are obtained from the results of the review. Discussion: Hydroxyapatite (HAp) is a bioceramic material formed from strong chemical bonds and is included in the bone components of living organisms (in vivo). Conclusion: Hydroxyapatite (HAp) is a bioceramic substance made up of a strong chemical link that is a derivative of calcium phosphate. It is commonly used in coatings or cements on bone because of its excellent biocompatibility.