Background:Acutekidneyinjury(AKI)is rare in women during pregnancy andpuerperiumhowever, it is related to increased morbidity and mortality rates. The present study was undertaken to assess the clinical profile and outcome of AKI during pregnancy and puerperium. Methods: This cross-sectional study was conducted on the total 94 pregnant and postnatal patients diagnosed with AKI during a period from July 2020 to October 2022. Results: Maximum patients (89.36%) were visiting the hospital at postnatal period of pregnancy, in the age group of 21-25 years (48.94%) and primipara (58.51%). Decreased urine output was the commonest clinical presentation (74.46%)and puerperal sepsis was the most common etiology for AKI (48.94%). Most common laboratory findings were anemia (75.53%). At presentation and on day 3 of admission, maximum cases had serumcreatinine level between 2-5 mg/dl, also, among death cases, 50% had serum creatinine levelbetween 2-5 mg/dl (50%).74.47% of patients required dialysis. Mean hospital stays were 10.23 days, mean blood transfused was 5.83 units, mean ICU stay was 4.11 days. Out of 94 patients, 81(86.17%) patients were recovered, 3(3.19%) patientshad CKD and 10(10.64%) patients were died. Most common cause of death was sepsis (40%).There was statistically significant association between dialysis required and outcome, (p<0.01). Conclusion: The maternal outcome after therapy is good as most of the patients were recovered. Improvement of pregnancy care, greater access to emergency obstetrics services, and an early diagnosis and referral could decrease the pregnancy related AKI and its consequences as well as reduce the burden of morbidity and mortality related to AKI.