Background :-An antifungal medication with a biological half-life of two hours, clotrimazole has gastrointestinal adverse effects when used orally at doses of 500 mg twice daily. The goal of this study is to create a transdermal drug delivery system for Clotrimazole and turmeric oil that will deliver the medication to a specific site to treat a fungal infection and lessen any potential sensitization or irritation issues. Method:- A turmeric oil is first extracted from the turmeric rhizomes, and then these transdermal patches were made using the solvent casting method using the placebo method. Different combinations of polymer were used with the solvents MDC and methanol in a 1:1 ratio, and polyethylene glycol 500 and propylene glycol were used as permeation enhancers and plasticizers. The manufactured patches were assessed for weight fluctuation, thickness, weight variation, moisture absorption, moisture uptake, folding endurance, flatness, drug content, and in-vivo permeation study during the analysis of the compatibility study RESULT:-In vitro drug release studies for all formulations revealed that the first dose of drug was released in 2 to 2.5 hours, and the complete dose was released (95%) within 24 hours. The formulation were uniform in their physical characteristics combinations of three polymers HPMC, EC, and EUDRAGIT RS-100, implying excellent quality and uniformity in patch characteristics as compared to other combinations of polymers. Conclusion:- Transdermal patches made of Clotrimazole and turmeric oil were successfully created, and their evaluation indicated good quality and uniformity in patch characteristics. These patches may have therapeutic effects and provide benefits such as lowering the frequency of doses required for treatment, increasing patient compliance, and increasing bioavailability. Keywords:-Clotrimazole, Turmeric oil, Eudragit RS 100,HPMC, EC, Transdermal drug delivery system